System requirements for FS2004:
Microsoft Flight Simulator 2004 (Version )
Windows XP / Vista/ Windows 7
Pentium 2,6 GHz or faster
1 GB RAM (2 GB advised)
3D graphics card with at least 256 MB (512 MB advised)
Download-Size: 180 MB
Installations-Size: 560 MB
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This action extends the prohibition of flight operations in the Tripoli (HLLL) Flight Information Region (FIR) by all . air carriers; . commercial operators; persons exercising the privileges of an airman certificate issued by the FAA, except when such persons are operating a .-registered aircraft for a foreign air carrier; and operators of .-registered civil aircraft, except operators of such aircraft that are foreign air carriers. The extension of the expiration date is necessary due to continued hazards to persons and aircraft engaged in such flight operations. This Special Federal Aviation Regulation (SFAR) will now remain in effect until March 20, 2019.
With chronic alcohol intake, consumption of ethanol similarly induces CREB phosphorylation through the D1 receptor pathway, but it also alters NMDA receptor function through phosphorylation mechanisms;   an adaptive downregulation of the D1 receptor pathway and CREB function occurs as well.   Chronic consumption is also associated with an effect on CREB phosphorylation and function via postsynaptic NMDA receptor signaling cascades through a MAPK/ERK pathway and CAMK -mediated pathway.  These modifications to CREB function in the mesolimbic pathway induce expression (., increase gene expression) of ΔFosB in the NAcc ,  where ΔFosB is the "master control protein" that, when overexpressed in the NAcc, is necessary and sufficient for the development and maintenance of an addictive state (., its overexpression in the nucleus accumbens produces and then directly modulates compulsive alcohol consumption).